Review: Pulmonary arterial hypertension

Published: 2010-06-25

Pulmonary arterial hypertension (PAH) is a rare and severe clinical condition characterised by a progressive increase of pulmonary vascular resistance leading to right ventricular failure and premature death. Free education on pulmonary arterial hypertension is published by the European Heart Journal [1].The article reviews PAH under the following headings:

• Pathogenesis
• Pathology
• Pathobiology
• Pathophysiology
• Progress of medical treatment in pulmonary arterial hypertension
• Traditional endpoints for clinical trials in pulmonary arterial hypertension
• Meta-analyses to assess the effect on mortality
• The way forward
• Combination therapy
• New candidate classes of drugs
• Future study designs

1. 10.1093/eurheartj/ehq152